Résumé
The study analyzed available literatures covering the organization of measures to combat the COVID-19 pandemic in the healthcare systems of the Russian Federation and several foreign countries. For the comprehensive assessment of the specifics of organizing measures to combat the COVID-19 pandemic, countries were chosen based on geographical distances from China (the closest is Korea, and the most remote are the Great Britain and Haiti), maximum population on their continent (the United States is in North America, and Brazil in South America), and significant differences in the functioning of the healthcare systems. The peculiarities of organizing measures to combat the COVID-19 pandemic in the considered countries were associated with a complex of political, financial, economic, demographic, and organizational factors, the individual combination of which determined the peculiarities of the development of the epidemic process in each specific case. Moreover, as a priority manifestation of the severity of these factors, the capabilities of the healthcare system, including the availability of services of medical workers, sufficient number of testing equipment, medical protection equipment, hospital beds, and other parameters, should be considered. The main role was played by global state strategies implemented in the healthcare systems of the analyzed countries at the pre-epidemic stage and, in most cases, aimed at optimizing the financial and economic provisions of state guarantees of medical care. The general criteria for the differential diagnosis of COVID-19 in the national recommendations of all the states considered were respiratory symptoms and general infectious intoxication. In addition, fever and respiratory symptoms were accepted as priority criteria for COVID-19 screening. © 2023 Vestnik Rossijskoj Voenno-Medicinskoj Akademii. All rights reserved.
Résumé
The experience of medical maintenance for assembly events annually held on the basis of the educational process of the Military Medical Academy named after S.M. Kirov. The main directions of the organization of sanitary and anti-epidemic (preventive) measures among the personnel at each stage of the camp gathering have been determined. It is shown that at the preparatory stage it is advisable to develop additional plans that concretize sanitary and anti-epidemic (preventive) measures for the stages of the camp gathering. At the stage of accepting participants, the main direction is the organization of events that prevent the introduction of infection with the arriving personnel. At the main stage of the camp training, the leading role belongs to disinfection measures. At the stage of departure of participants, the main efforts should be focused on minimizing the potential risk of infection along the route and the introduction of infection into their military units. The features of disinfection are described depending on the type of object being processed. The results of testing a designed device for fixing dispensers with a skin antiseptic on the basis of a unified military stand in a camp gathering are presented. The features of the organization of medical control over the material and household provision of the personnel of the training camp are stated. The basic principles of prophylaxis and anti-epidemic protection during assembly activities in the context of the spread of COVID-19 have been formulated. © 2019 Eco-Vector LLC. All rights reserved.
Résumé
The morbidity of the new coronavirus infection (COVID-19) in the Russian Armed Forces is decreasing thanks to the sanitary and preventive anti-epidemic measures, the most effective of which is mass vaccination. The purpose of this research was to study the peculiarities of the formation of herd immunity among adolescent students of the Russian Ministry of Defense (MoD) colleges against the background of the COVID-19 epidemic. Materials and methods of the research: according to the epidemic indications, a two-stage seroepidemiological multicenter prospective study of herd immunity to SARS-CoV-2 was carried out in Dec. 2021 - May 2022, against the background of vaccination, among adolescent students of the Russian Defense Ministry colleges. 515 adolescents aged 11 to 17 years old (median age 13 [12;15] years old) from the two Russian MoD schools located in the city of Saint Petersburg, of which 292 (57%) girls and 223 (43%) boys, were involved in the study. The adolescents were divided into groups based on gender and previous COVID-19 illness e.g., those who already had COVID-19 and those who had not prior to the study. In the second stage of the study the number of samples from boys and girls decreased by 74.3% and 34.4%, respectively, due to the lack of parents' consent to the vaccination. The assessment of the immunity intensity was carried out using the Anti-SARS-CoV-2 IgG levels in blood serum by enzyme-linked immunosorbent assay (ELISA). Result(s): the initially high levels of seroprevalence to SARS-CoV-2 were established among both girls and boys (90.4% and 91.5%, respectively, p=0.09) that indicated a latent course of the epidemic process in the studied groups of teenagers. In adolescent girls and boys vaccinated against the background of a previous COVID-19 illness, the combined immunity is formed in 62.3% and 68.1%, respectively (p=0.11). Conclusion(s): the epidemic process of COVID-19 tends to be latent in organized adolescent groups, being realized in inapparent forms of the infection. Those adolescents who've been vaccinated after COVID-19 illness develop the immunity with positive seroconversion dynamics. Copyright © 2022, Pediatria Ltd. All rights reserved.
Résumé
Relevance. Despite the implementation of measures to reduce morbidity and mortality among medical workers who are in contact with patients hospitalized for a new coronavirus infection caused by SARS-CoV-2 (hereinafter – COVID-19), their level remains high today. Given the difficulty of achieving the required number of vaccinated to form collective immunity, the issue of finding additional drug-based ways to prevent COVID-19, especially in risk groups, becomes urgent. Aims. To evaluate the effect of azoximer bromide on the number of cases of confirmed COVID-19 disease among medical workers, as well as on the level of chronic fatigue in the study groups. Materials and methods: 78 men and women were included in the study. The experimental group consisted of 41 people who took azoximer bromide for 38 days. The comparison group consisted of 37 people who were not prescribed azoximer bromide. The epidemiological efficacy of the drug was evaluated. Statistical evaluation of the significance of the differences was carried out using the Student's t-test, Pearson's criterion χ2. Results. The number of study participants with COVID-19 in the experimental group was significantly lower than in the comparison group. A significantly faster reduction of manifestations of chronic fatigue syndrome was noted in study participants who took azoximer bromide. There were no adverse events during the administration of the studied drug by the study participants. Conclusions. Azoximer bromide has shown epidemiological efficacy when used by medical workers directly providing medical care to patients with COVID-19 (when working in the «red zone»), including contributing to the more rapid normalization of the psychological state of medical workers. © Kasyanenko KV, et al.
Résumé
Background. The need to study the population immunity to the SARS-CoV-2 virus is due to the intensive spread of COVID-19 and the implementation of immunoprophylaxis of this infection. The identification of the features of the formation of immunoresistance in organized military collectives will allow us to predict the development of the epidemic situation, including among comparable population groups. Aims ' the study of population immunity to the SARS-CoV-2 virus in the context of the COVID-19 pandemic against the background of specific immunoprophylaxis in organized military collectives. Methods. According to epidemiological indications, an epidemiological study of collective immunity to the SARS-CoV-2 virus was conducted against the background of vaccination among cadets of military educational organizations. The study involved 497 people, divided into groups by epidemiological and vaccination history for COVID-19, blood groups and Rh factor. The assessment of the immunity intensity was carried out by the levels of class G immunoglobulins (IgG) to SARS-CoV-2 in the blood serum by the method of solid-phase enzyme immunoassay. Results. Seroprevalence in the total sample was 92.6%. The highest rates were observed among vaccinated patients: those who were not ill and vaccinated ' 99.0 ± 0.7%, those who were ill and vaccinated-100% (mean geometric antibody titers ' 1:2234 and 1:4399). Among the ill, unvaccinated individuals, the seroprevalence index was 84.5 ± 3.2% (1:220). Among those who were not ill, not vaccinated ' 8.2 ± 3.1% (1:113), which may indicate a hidden course of the epidemic process in the team. A negative immune response was more common (tSt = 2.01;p < 0.05) in individuals A(II)Rh+ blood group. The highest proportion of maximum antibody titers (1:3200-1:6400) was determined in AB(IV) individuals. Rh-blood groups (tSt=2.21;p < 0.05). Conclusions. For the first time, the formation of combined immunity with the highest concentrations of specific antibodies was revealed in patients who have been ill and vaccinated has been revealed, which allows us to recommend vaccination to those who have suffered from COVID-19. The emergence of post-infectious immunity in organized groups with a latent epidemic process has been established. The relationship between the intensity of immunity with blood groups and the Rh factor was found. © 2021 Izdatel'stvo Meditsina. All rights reserved.
Résumé
The experience of medical maintenance for assembly events annually held on the basis of the educational process of the Military Medical Academy named after S.M. Kirov. The main directions of the organization of sanitary and anti-epidemic (preventive) measures among the personnel at each stage of the camp gathering have been determined. It is shown that at the preparatory stage it is advisable to develop additional plans that concretize sanitary and anti-epidemic (preventive) measures for the stages of the camp gathering. At the stage of accepting participants, the main direction is the organization of events that prevent the introduction of infection with the arriving personnel. At the main stage of the camp training, the leading role belongs to disinfection measures. At the stage of departure of participants, the main efforts should be focused on minimizing the potential risk of infection along the route and the introduction of infection into their military units. The features of disinfection are described depending on the type of object being processed. The results of testing a designed device for fixing dispensers with a skin antiseptic on the basis of a unified military stand in a camp gathering are presented. The features of the organization of medical control over the material and household provision of the personnel of the training camp are stated. The basic principles of prophylaxis and anti-epidemic protection during assembly activities in the context of the spread of COVID-19 have been formulated.